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Kipnis notes that for some individuals, the injection may be a better option

10.1523/JNEUROSCI.1309-11.2011 4

A physician-guided formula, or one paired with microneedling, reaches more of the tissue that matters

Biochem Biophys Res Commun 291:13021308 Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE, Sitagliptin 036 Study Group (2007) Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes

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If headaches become frequent or severe, consult a healthcare provider for evaluation