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Additionally, the neurogenic locus notch homolog protein 1 (NOTCH1) signalling pathway [133] and the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) pathway [176, 177], have also been shown to augment NFE2L2 transcription, and consequently activate NRF2 signalling, thus maintaining redox balance
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View Source Nature Communications MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis 2021 DOI: 10.1038/s41467-020-20790-0 PMID: 33483561 Reynolds JC, Lai RW, Woodhead JST, et al
Its presence indicates a significant role in maintaining the cellular health of both the mother and the developing fetus
Pharmacological activation of the System Xc-/GSH/GPX4 axis has emerged as a promising avenue for the management of ferroptosis-related ocular diseases, as it can suppress ferroptosis by replenishing GSH precursors, upregulating the expression or activity of SLC7A11, or directly stabilizing GPX4 protein to resist its inactivation (132)
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