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Cozza G, Rossetto M, Bosello-Travain V, Maiorino M, Roveri A, Toppo S et al (2017) Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: the polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

Distinguish in vitro (cell-culture studies), in vivo (animal models, mostly rodents), and clinical (human trials) research

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The probe can selectively illuminate hepatoma cells and show enhanced deep tumor penetration both in vitro and in vivo by charge conversion

In conclusion, patients with G6PD deficiency are notorious for elevated levels of ROS in response to classic triggers including viral infections such as COVID-19