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Using a U-40 syringe with U-100 calculations results in a 2.5x overdose

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The concentrations are: 0.25 mg/0.5 mL (0.5 mg/mL) 0.5 mg/0.5 mL (1 mg/mL) 1 mg/0.5 mL (2 mg/mL) 1.7 mg/0.75 mL (2.27 mg/mL) 2.4 mg/0.75 mL (3.2 mg/mL) Important safety consideration : Patients should never attempt to measure semaglutide doses by volume or extract medication from pens using syringes

Hurot JM, et al

This suggests that precise dosing may be less critical than consistent daily administration over an adequate duration