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The hydrogen bond network was then optimised and the protein structure minimised to a root mean square deviation of 0.3 with the OPLS4 forcefield [32]

When used locally with chemotherapeutic medications like oxaliplatin for breast cancer treatment, puerarin improved chemotherapy sensitivity, suppressed oxaliplatin-induced EMT, and inhibited the CAXII enzyme, which prevented type III drug resistance and breast cancer metastasis (139)

Multiple studies in rodent models of colitis and NSAID-induced gastrointestinal damage have shown significant protective and healing effects

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