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For example, Zhang et al (177) developed PMVL, a lonidamine-loaded nanoplatform that enhances ferroptosis and immune activation through dual inhibition of glycolysis and the PPP, effectively reducing lactate production

Development of alternative forms

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According to FDA regulatory status, these peptides are not FDA-approved for human use and are intended for research use only

26 and Oubeid et al

MK-677's longer half-life and oral availability make it more convenient but also more detectable