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The key preclinical data urgently needed before clinical trials can commence include: (i) efficacy and immune-profiling data derived strictly from clinically relevant orthotopic and spontaneous pulmonary metastasis models, rather than simple ectopic subcutaneous models

Comparative analyses of polyamine levels in human normal, benign, and malignant prostatic tissues reveal elevated spermine concentrations in normal and benign hyperplastic prostates, contrasting with reduced spermine levels in tumor tissues, particularly metastatic prostate cancer (65)

If its not solving a problem, it is a problem, toss it out

BPC-157 and TB-500 have distinct pharmacokinetic properties that researchers should account for when designing dosing intervals and endpoint measurements

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PMID: 305 TiwariAMishraSKuoTR