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( C ) Schematic of IRI protocol and ( D ) percentage of LVDP recovery of isolated WT mouse hearts with the sAC inhibitor KH7 (20 mol/L) or the tmAC inhibitor Ddox (50 mol/L) prior to perfusion with buffer only (Cntl), scrambled(2836), GLP-1(2836), or GLP-1 ( n = 3/group)
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Dose-dependent effects: Safety concerns increase substantially at doses exceeding 5060 mcg/day
Landmark findings from the STEP UP trials Tripling the standard dose of semaglutide a widely prescribed glucagon-like peptide-1 receptor agonist (GLP-1RA) resulted in markedly greater weight loss and cardiometabolic benefits, according to results from two large multicentre clinical trials led by UT Southwestern Medical Center
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