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The glutathione system comprises the enzymes that synthesize glutathione within a cell as well as dedicated enzymes that use glutathione (GSH) as the means to exert antioxidant effects
Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects
These reactions can make up 60% of bile metabolites in some cases
Indeed, iron-dependent neuron loss was described in -synucleininduced neuronal death well before the emerging concept of ferroptosis (6), though evidence linking lipid peroxidation, ferroptosis, and synucleinopathy has been lacking
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