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Treatment with L-carnitine at a dose of 300 mg/kg showed more powerful antioxidant effects than the lower dose (150 mg/kg) concerning GSH levels in the prefrontal cortex and hippocampus and hippocampal MDA levels
Moreover, increased levels of ubiquitination and proteasomal activity are observed in tissues from individuals with dilated cardiomyopathy
DOI: 10.1016/j.redox.2022.102355
Tirzepatide itself is not primarily metabolized by these enzymes, which means direct pharmacokinetic interaction between berberine and tirzepatide is not the main concern
GIP receptors in the brain may modulate different aspects of energy homeostasis, including energy expenditure and food reward pathways
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