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Mean diabetes duration ranges from 5.2 2.8 years (Mokhtari et al., 2021) to 15.3 4.1 years ( 5.6.4 Endpoint selection and standardization Across the 12 RCTs, seven different primary endpoints were used (VAS, TCSS, NDS, VPT, NSS, SNAP, SNCV), and only two trials adopted composite scores recommended by the Toronto Consensus on Diabetic Neuropathy (Pop-Busui et al., 2017)

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