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The complete chemical structure of the molecule was determined by Dorothy Hodgkin based on crystallographic data and published in 1955 [147] and 1956, [148] for which, and for other crystallographic analyses, she was awarded the Nobel Prize in Chemistry in 1964
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It is one of the most heavily cited peptides in preclinical tissue-repair, angiogenesis and gastrointestinal barrier research literature over the last two decades
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