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Typical conversions from animal studies use body-surface-area scaling: Rat dose: 10 g/kg human equivalent ( 0.162) 1.6 g/kg For a 70 kg adult: ~112 g per day Self-experiment protocols often cite 100200 g once or twice daily via subcutaneous injection

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Research indicates that the reduction in serum B12 levels typically becomes clinically significant after several years of continuous metformin therapy

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