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People with irritable bowel syndrome (IBS) or certain other conditions may experience diarrhoea more frequently than others

Higher temperatures increase the activity of molecules and can lead to degradation and lower temperatures can cause ice crystals to form and phases to separate

This is the therapeutic sweet spot for many researchers, where the balance of efficacy and tolerability optimizes

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Also, persons with health conditions like HIV, celiac disease, and Crohns disease may find it difficult to absorb vitamin B effectively