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However, it is wise to avoid a very large or heavy meal immediately before your first dose, as the slowed digestion might make you feel uncomfortably full or nauseated as the medication begins to circulate

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For type 2 diabetes management , NICE guidance (NG28) recommends GLP-1 agonists as second- or third-line therapy when metformin and other oral agents provide inadequate glycaemic control, or as an alternative to insulin in appropriate patients

Participants are included if they reported an adverse effect of GLP-1 agonist and reported the cumulative dose of drug administered

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