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The benefit of GLP-1 RAs exceeded the harms for weight loss in the first 2 years of treatment, yet the net benefit was dependent on individual treatment goals (10% or 5% weight loss) and willingness to accept harms in pursuit of weight loss
My trial was only eight weeks
The expression of relative mRNA was normalized to that of the housekeeping gene 18S.Primer sequences used are provided in Supplementary Table 2
The mice were randomly divided into four groups (each containing at least five mice): a natural aging group, a natural aging + FOXO4-DRI group, a D-Gal group, and a D-Gal + FOXO4-DRI group
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The peptide mice were reported to have experienced considerable weight loss, suggesting that the peptide may not depend on the lipolytic receptors to exert any action
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