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Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, et al

Although AD and VaD share common vascular risk factors, the contribution of small artery disease to VaD pathogenesis may be greater than that of AD [120].In fact, studies have found that neuropathic changes can be evident 20 years before the onset of dementia and that there is a substantial neuronal loss in the MCI stage, which is considered a transitional state before the onset of dementia [121]

In contrast, the prolyl isomerase cyclophilin D in the mitochondrial matrix is an essential regulator of MPT and the only genetically proven indispensable MPT component (Nakagawa et al., 2005

Insert air into the vial: Remove the cap from the needle and push the needle through the rubber stopper at the top of the vial

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The supernatant was used as the deproteinized fraction