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Finally, there is the concern of self-directed experimentation

In addition, activation of GLP-1R in the brain is albe to reduce appetite, lowering the risks for other diseases such as metabolic and cardiovascular disorders (88)

R.et al (2015)

Characterized by cell injury and inflammatory cell infiltration, NASH is regarded as a more aggressive form of NAFLD possibly progressing to cirrhosis and hepatocellular carcinoma with limited treatment options (118) and with a history of NASH, the possibility of suffering liver and cardiovascular diseases is greatly increased (119)

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