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Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-B

But it is fragile and breaks down quickly

[Effects of flavonoids from Gynostemma pentaphyllum on A549 cells damaged by hydrogen peroxide]

This results in increased proteasomal degradation of oxidatively damaged proteins as well as p62, thereby facilitating ATG-lysosomal degradation of proteins and dysfunctional organelles, such as the mitochondria (Levonen et al., 2014)

The PRIDE database resources in 2022: A hub for mass spectrometry-based proteomics evidences