doi:10.1101/2021.03.15.435309 9
When mild effects occur, they are usually limited to temporary digestive symptoms such as bloating, gas, nausea or loose stools, and these are dose-dependent (more common above 12 g/day, which is far higher than typical fertility use)
C., Kohn, J
Additionally, estrogen-stimulated cyclooxygenase-2 (COX-2) activity drives prostaglandin E2 (PGE2) synthesis, creating a positive feedback loop that enhances local estrogen production and inflammation, further facilitating ectopic implantation ( 2.2 Immune system dysfunction and chronic inflammation Immune system dysfunction and chronic inflammation are central pathological features underlying endometriosis-associated infertility, characterized by aberrant immune cell activation, cytokine dysregulation, and impaired immune surveillance
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