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Despite advances in antimicrobial therapy and supportive care, sepsis continues to result in high morbidity and mortality, with an estimated 48.9 million cases and 11 million deaths worldwide in 2017, accounting for nearly 20% of all global mortality, disproportionately affecting low- and middle-income countries (Rudd et al., 2020)
It does NOT mean the combination is pharmacodynamically neutral
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Lean body mass is everything except fat, including bones, muscles, organs, blood and skin
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