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While this lean mass loss is proportional to the total weight loss and generally considered acceptable, it underscores the importance of resistance training and adequate protein intake during treatment

Obesity and insulin resistance are risk factors, along with genetics

A systematic review reveals that GLP-1 receptor agonists may help reduce certain substance use disorders, but findings are inconsistent due to study variability and patient differences

Tirzepatide became the first dual GLP/GLP-1 receptor agonist to gain FDA approval for treating T2DM in 2022 and obesity in 2023 [ Table 2 ]

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