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This effect is believed to be due to IGF-1 suppression of insulin secretion, which leads to augmented lipolysis in adipose tissue and promotion of FFA use by muscle

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Concurrent use would be pharmacologically incoherent: one agent removes copper while the other delivers it

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Research indicates that although semaglutide did not significantly improve hepatic fibrosis, it had positive effects on hepatic steatosis, weight control, and diabetes-related parameters, offering a new therapeutic direction for patients with NASH and compensated cirrhosis (Flint et al., 2021