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SA forms an active monomeric form by regulating the depolymerization of NPR1

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The study assessed various clinical and biochemical markers, including body weight, body mass index (BMI), waist circumference (WC), total fat mass, and visceral fat, as well as such inflammatory markers as the PASI and the Disease Activity Index of Psoriatic Arthritis (DAPSA)

This approach can reduce peak-related side effects like nausea while maintaining the same total weekly dose