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Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing
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Collectively, the results of this study demonstrated that ( 2 O 2 generation is essential for the EGF-induced activation of the PI3K/AKT/p70S6K1 pathway ( 2 O 2 transcriptionally mediates EGF-induced VEGF expression through AKT/p70S6K1 signaling, and ( 2 O 2 production are essential for ovarian tumor angiogenesis (31)
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