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A study published in The New England Journal of Medicine found that the share of GLP-1 prescriptions written for people who were not diabetic, obese, or overweight climbed from 4.5 percent in 2018 to 17 percent in 2023

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In a direct comparison, the dual agonists DA4-JC and DA5-CH were able to cross the BBB much better than standard GLP-1 receptor agonists, such as exendin-4, liraglutide, and semaglutide (Li et al., 2020

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