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Treatment response : As per NICE guidance, assess response after 6 months and continue only if adequate benefit is demonstrated (HbA1c reduction of at least 11 mmol/mol [1%] and/or 3% weight loss from initial body weight)
Instead, by improving metabolic regulation and reducing chronic inflammatory stress, GLP-1 signaling may alter the cellular environment in ways that support more effective management of accumulated molecular damage
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Common side effects Nausea Vomiting Diarrhea Constipation Fatigue Decreased appetite Gas/burping Abdominal cramping Less common but more serious side effects Gallbladder issues Pancreatitis Severe digestive discomfort Kidney concerns in dehydrated individuals Providers often start patients on low doses to improve tolerability
Glucagon also appeared to Marks to enhance 'glucose assimilation in normal subjects'
Chin J Nat Med 2020;18:80317
