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Active VD supplementation reverses SERCA2a/PLB ratio decline and compensatory NCX upregulation caused by VD signaling defects, improving calcium handling and contractile dysfunction (Choudhury et al., 2014)

This FAO shift increased the activity of immunosuppressive enzymes and promoted the generation of regulatory T cells, leading to tumor-mediated immune tolerance

By amplifying HGF signalling at c-Met it switches on the intracellular PI3K/Akt and MAPK/ERK cascades precisely those that govern synaptogenesis, neuroplasticity and neuronal survival

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Suppressed milk production is also likely due to the loss of iodine and thyroid hormones to the milk