Our knowledge of the transcriptional regulation mediated by T3 and its receptor TR has been greatly expanded recently by taking advantage of the genome-wide ChIP-seq analysis and expression analysis after acute and chronic TH treatment as well as during TH state transition 23,24,25,26,27,28
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Postulated to be driven by excess centripetal/visceral fat and/or dysbiosis in gut microbiome
The major findings from these studies are summarized below
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