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This combination may result in excessive drowsiness, impaired coordination, slowed reaction times, and, in severe cases, respiratory depression
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Risk is highest during the initial titration phase and subsequent dose increases, particularly in vulnerable populations such as older adults or those with pre-existing conditions
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Because retatrutide has not yet received MHRA or EMA approval, it is not currently available through NHS prescriptions or licensed private clinics in the UK
Sachdeva et al., 2022)
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