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Toxicol Sci 127:582-591
B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T
Rather than observing increasing and persistent JNK activation (persistent pJNK), rising ROS levels, peroxynitrite formation, and release of Endo G and AIF, instead they found pJNK decreased over time to undetectable levels, and hepatic necrosis was prevented ( Figure 22 )
doi: 10.1038/s44321-025-00324-1 61 ZhangZYangWWangLZhuCCuiSWangTet al
39 Another study demonstrated that after 6 months, the combination of FCS with mini-punch grafting (a tissue-cellular hybrid approach) yielded significantly better repigmentation than either technique alone, highlighting the additive benefit of incorporating follicular-derived cells
Conclusion Melatonin could exert a beneficial effect in people suffering from MS, running as a promising candidate for the treatment of this disease
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