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Drach J, Pereira-Leahy JM, Goodacre A, Drach D, Sanchez-Williams G, Weier HU, Pinkel D, Andreeff M

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In silico profiling has demonstrated that the severity of diabetic tubulointerstitial injury correlates significantly with the dysregulation of CASP1 and LYZ, both of which represent pivotal hub genes orchestrating NET formation and clearance (221)

While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

Safety, Efficacy, and Determination of the Recommended Phase 2 Dose for the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330)

Nguyen, K., Dersnah, G