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Transforming growth factor-beta receptor activation represents another key mechanism underlying GHK-Cu's effects on matrix synthesis and tissue remodeling

Here, we engineer a next-generation probiotic by subjecting EcN to iterative H 2 O 2 -driven evolution to select for strains that couple ROS detoxification with metabolic adaptations favoring energy-efficient redox balancing, followed by sequential modification with fructooligosaccharides (FOS) and CaCO 3 mineralization