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Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
Front Immunol (2017) 8:609
In addition, our results suggest a novel mechanism involving low GSH-associated AMPK activation that prevents alcohol-induced steatosis, which challenges the existing knowledge on the role of low GSH in alcoholic liver disease
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It is synthesized primarily in the liver, though individual cells can help regulate their own intracellular glutathione levels based on metabolic need
Presenting symptoms for irAEs can be nonspecific and at times subtle making them difficult to be identified
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