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Once the protein has denatured, the damage is permanent
Similarly, Rybelsus has relatively low oral bioavailability and requires very specific conditions for absorption: it must be taken with no more than 120ml of water, on an empty stomach, with no food, drink, or other oral medications for at least 30 minutes afterwards
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Exenatide weekly, Liraglutide &Dulaglutide have the most reduction effect on HbA1c ( Table 3 ) Table 3: GLP-1RAs summary of head-to-head clinical trials
It also notes these carry fewer acute safety risks
Injection site reactions such as redness, itching, or mild discomfort occur in approximately 2-4% of patients but are generally mild and self-limiting
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