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This literature review was conducted following the PICO Framework, with details available in Supplementary material 1

Those with a familial or personal history of medullary thyroid cancer or certain endocrine conditions should avoid this treatment

30-year results of a randomised trial

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The side effects of tirzepatide are the same as the GLP-1 medications, primarily nausea and gastrointestinal disturbance

Week 4 (End of Month 1): By the end of week 4, most patients on semaglutide have lost 3 to 4% of their starting body weight