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In the absence of vitamin C, impaired collagen formation occurs due to a deficiency in the hydroxylation of procollagen and collagen

There have also been documented local skin reactions when using GLP-1 RAs, particularly with the long-acting formulations

According to the Global Burden of Disease Study, both type 1 and type 2 diabetes mellitus substantially contribute to chronic kidney disease (CKD)-related disability-adjusted life-years (DALYs)

Diabetes-related factors, including neuropathy affecting nerves that control the gastrointestinal tract [41, 42] and changes in gut motility [43], can lead to slowed digestion, constipation, and potential bowel obstruction