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In the first study, fasted healthy mice were submitted to an intraperitoneal glucose tolerance test (IPGTT) 5 min after dosing 1 and 14 in order to validate the activity of the reference peptide 1

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Therefore, there are multiple factors to consider when outlining the biggest differences between the two melanocortin agonists: Molecular Structure: While both MT1 and MT2 are synthetic analogs of alpha-MSH, they have only four amino acids in common: the sequence His-D-Phe-Arg-Trp (positions three to six in MT2)

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However, FXR activation decreases both proglucagon mRNA levels and GLP-1 secretion in response to glucose [175, 176]

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