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should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus Discontinue treatment in women at least 2 months before a planned pregnancy, owing to the long washout period for semaglutide Clinical Considerations Poorly controlled diabetes during pregnancy increases maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, stillbirth, and delivery complications Poorly controlled diabetes increases fetal risk for major birth defects, stillbirth, and macrosomia-related morbidity Lactation There are no data on the presence of semaglutide in human milk, the effects on the breastfed infant, or the effects on milk production In lactating rats, semaglutide was detected in milk at levels 3- to 12-fold lower than in maternal plasma Interaction Coadministration with insulin secretagogues (eg, sulfonylureas) or insulin may increase the risk of hypoglycemia

At their worst, side effects such as vomiting and nausea or hypoglycemia can land you in the emergency room

GLP-1 medications enhance insulin sensitivity and help regulate glucose levels, which can provide a more consistent energy supply

Do not aspirate

Reconstitution Guide Allow the vial to reach room temperature, then sterilise the rubber stopper of both the glutathione vial and the bacteriostatic water vial with an alcohol swab

Find additional tips, troubleshooting help, and resources within our Protein Purification and Isolation Support Center.