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This biased agonism refers to the fact that tirzepatide selectively engages cAMP signaling over -arrestin recruitment at the GLP-1R, which may augment cellular response via beneficial impact on GLP-1R cell surface trafficking, leading to increased cell surface expression

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Jaiswal P, Tripathi V, Nayak A, Kataria S, Lukashevich V, Das AK, et al

It may be considered when supplemental L-Glutathione is indicated

this dual action appears to produce greater weight loss than GLP-1 agonism alone, as shown in head-to-head metabolic modeling and indirect comparison analyses