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Briefly, these studies revealed that DSePA treatment (at concentrations which are non-toxic for normal cells) inhibited the growth of lung cancer cells by causing reductive stress (marked by the increase in the levels of GSH and GPx) followed by mitochondrial and endoplasmic reticulum-dependent apoptosis [92]

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GCL/GSH1 is exclusively located in plastids in higher plants and encoded by a single gene in A