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The IGF-1R promoter exhibits a high basal transcriptional activity, and is under physiological control of nutritional factors (Olchovsky et al, 1993), hormonal stimulation (Clarke et al, 1997) and the developmental stage (Bondy et al, 1992)

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In addition, PKA inhibition attenuated the effects of metformin on PA-induced endothelial dysfunction, suggesting that PKA may be involved in the protective effects of metformin on endothelial cells

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is preferred, as in our experience, it is always free of interference

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