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The 612 week period is when many patients reach their optimal dose, as earlier side effects no longer obscure whether they need dose escalation to maximize weight loss
Available at: Endocrine Society
The threshold concentration for tubular reabsorption (above which the fractional reabsorption begins to decline) is about 40-60 umol/L, which is similar to the endogenous plasma L-carnitine level
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Others lose less, especially if they were previously eating in a deficit and have less initial water weight to release
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