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Safety and Tolerability Across trials, retatrutides most common side effects were mild to moderate gastrointestinal issues (nausea, vomiting, diarrhea, constipation), particularly during dose escalation

Hyperpigmentation - Fades dark spots caused by sun damage, such as freckles, liver spots, and melasma

The recommended daily dose of 300 mg corresponds to the approach used in functional nutrition

Laboratory Tests During the initial treatment of patients with pernicious anemia, serum potassium must be observed closely the first 48 hours and potassium replaced if necessary

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Even the most bioavailable supplement needs a supportive environment to work effectively