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No systematic trend was noted for this increase in exposure across different renal impairment subgroups

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The most pronounced effect among commercially available agents came from once-weekly tirzepatide 15 mg (Zepbound, Eli Lilly), which resulted in weight loss of up to 17.8% (95% CI, 16.3%-19.3%) after 72 weeks of therapy

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Individual responses will vary, and patients should not expect immediate or dramatic results in the earliest stages of treatment