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Understanding these mechanisms helps clinicians select the most appropriate GLP-1 agonist for individual patients and set realistic expectations regarding tolerability

1 Introduction CKD, which is defined by the gradual loss of kidney function and progressive structural damage, has become a pressing public health concern globally, including in China

Effects of switching from dipeptidyl peptidase 4 inhibitors to oral semaglutide on oxidative stress and glycemic variability in patients with type 2 diabetes: an open-label, prospective, randomized, multicenter, parallel-group comparison study

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Additional classification is based on the regions of injury: focal injury encompasses mass lesions like contusions, subdural hematoma, epidural hematoma, and intra-parenchymal haemorrhage, while diffuse injury involves axonal, hypoxic-ischemic and micro-vascular injuries (Leitgeb et al., 2012)

IL-1 and the intestinal epithelial tight junction barrier