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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide
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Diane Duncan today and discover how Plastic Surgical Associates can help you achieve lasting results
Rekha Kumar, the GLP-1 class of medicines signals fullness to the brain and regulates blood sugar
10.1016/S0140-6736(18)32261-X 10
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