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[Source: Fierce Pharma ] January 2025 The FDA fast-tracked tirzepatide for cardiovascular risk reduction in obesity patients, following landmark trial results showing significant benefit beyond weight loss
Changes in HbA1c throughout the study were also not associated with reduced MACE.24 Additionally, the multiple pleiotropic effects of SEMA on metabolic, hepatic and renal function may indirectly contribute to cardiovascular protection.25 The HFpEF programme shows significant symptomatic improvement of heart failure symptoms with preserved ejection fraction (HFpEF) in obese patients treated with SEMA 2.4 mg26 (Fig
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