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Lixisenatide and renal outcomes in patients with type 2 diabetes and acute coronary syndrome: an exploratory analysis of the ELIXA randomised, placebo-controlled trial

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Common factors: a dose that never arrived, degraded peptide (storage is the usual culprit), underlying inflammation blocking repair (where KPV enters some protocols), injection technique, or a stalled structural-repair phase, where TB-500 is the common addition

NICE guidance acknowledges that response to treatment varies between individuals