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In laboratory peptide signaling studies, DAC-linked formats are generally described as having a longer observable activity window, while non-DAC formats are discussed in relation to shorter pulse-oriented signaling behavior

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This includes test subjects with hypophysectomy, hypopituitarism, pituitary tumor/surgery, head irradiation, or even head trauma [23]

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In addition, NDBs such as collagen, gelatin, dextran, agarose/alginate, hyaluronic acid, cellulose, and fibrin are also being explored in various other biomedical applications, including open incision/wound suturing, fixing, adhesion, covering, occlusion, isolation, contact inhibition, cell proliferation, tissue guiding, and controlled drug administration (Baranwal et al., 2022)

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